Ephedra To Pump Your Adrenaline Up !

Ephedra refers to the plant Ephedra sinica. E. sinica, known in Chinese as ma huang (麻黃; pinyin: má huáng), has been used in traditional Chinese medicine for 5,000 years for the treatment of asthma and hay fever, as well as for the common cold. Several additional species belonging to the genus Ephedra have traditionally been used for a variety of medicinal purposes, and are a possible candidate for the Soma plant of Indo-Iranian religion. Native Americans and Mormon pioneers drank a tea brewed from an Ephedra, called Mormon Tea.

In recent years, the safety of ephedra-containing dietary supplements has been questioned by the United States Food and Drug Administration (FDA), the National Center for Complementary and Alternative Medicine, and the medical community as a result of a high rate of serious side effects and ephedra-related deaths. In response to accumulating evidence of adverse effects and deaths related to ephedra, the FDA banned the sale of ephedra-containing supplements on April 12, 2004. A suit by an ephedra manufacturer was upheld by a Federal District Court judge in Utah on April 14, 2005. The FDA appealed this ruling, and on August 17, 2006 the U.S. Court of Appeals for the Tenth Circuit upheld the FDA's ban of ephedra.As of June 2007, the sale of ephedra-containing dietary supplements remains illegal in the United States due to their health risks.

Effects and uses

Ephedra is both a stimulant and a thermogenic; its biological effects are due to its ephedrine and pseudoephedrine content. These compounds stimulate the brain, increase heart rate, constrict blood vessels (increasing blood pressure), and expand bronchial tubes (making breathing easier). Their thermogenic properties cause an increase in metabolism, evidenced by an increase in body heat.

In traditional Chinese herbology, E. sinica is included in many herbal formulas that treat cold and flu such as 麻黃湯 ma huang tang (ephedra decoction) or 麻杏石甘湯 ma xing shi gan tang (ephedra, apricot kernel, gypsum, and licorice decoction). Ephedra is used therapeutically as a diaphoretic to help expel exterior pathogens and regulate the proper functioning of the lungs.

Ephedra is widely used by athletes, despite a lack of evidence that it enhances athletic performance. Ephedra may also be used as a precursor in the illicit manufacture of methamphetamine.

Ephedra has also been used for weight loss, sometimes in combination with aspirin and caffeine. Some studies have shown that ephedra, when taken in a regulated and supervised environment, is effective for marginal short-term weight loss (0.9kg/month more than the placebo), although it is unclear whether such weight loss is maintained. However, several reports have documented the large number of adverse events attributable to unregulated ephedra supplements.

Side effects of ephedra may include severe skin reactions, irritability, nervousness, dizziness, trembling, headache, insomnia, profuse perspiration, dehydration, itchy scalp and skin, vomiting, hyperthermia, irregular heartbeat, seizures, heart attack, stroke, or death.

Use in sports

Ephedrine is listed as a banned substance by both the International Olympic Committee and the World Anti-Doping Agency. The U.S. National Football League banned players from using ephedra as a dietary supplement in 2001 after the death of Minnesota Vikings offensive tackle Korey Stringer; ephedra was found in Stringer's locker and was believed by some to have contributed to his death.The substance is also banned by the National Basketball Association. Nonetheless, ephedra remains widely used by athletes; a 2006 survey of collegiate hockey players found that nearly half had used ephedra in the belief it would enhance athletic performance.

Purity and dosage

There are no formal requirements for standardization or quality control of dietary supplements in the United States, and the dosage of effective ingredients in supplements may vary widely from brand to brand or batch to batch. Studies of ephedra supplements have found significant discrepancies between the labeled dose and the actual amount of ephedra in the product. Significant variation in ephedrine alkaloid levels, by as much as 10-fold, was seen even from lot to lot within the same brand.

Safety and regulatory actions in the United States

Escalating concerns regarding the safety of ephedra supplements led the FDA to ban the sale of ephedra-containing supplements in the United States in 2004. This ban was challenged by supplement manufacturers and initially overturned, but ultimately upheld.

info : wikipedia

Herbal Plant : Willows

Willows Plant use as an Antipyretic

Willows (Salix) are a genus of around 400 species of deciduous trees and shrubs, found primarily on moist soils in cold and temperate regions of the Northern Hemisphere. Some of the shrub and smaller tree species may also be known by the common names osier and sallow; the latter name is derived from the same root as the Latin salix. Some willows, particularly arctic and alpine species, are very small; the Dwarf Willow (Salix herbacea) rarely exceeds 6 cm in height, though spreading widely across the ground.

Willows are very cross-fertile and numerous hybrids occur, both naturally occurring and in cultivation. A well known example is the Weeping Willow (Salix × sepulcralis), very widely planted as an ornamental tree, which is derived from hybridisation between the Chinese Peking Willow and the European White Willow.

Medical Use

The leaves and bark of the willow tree have been mentioned in ancient texts from Assyria, Sumer and Egypt as a remedy for aches and fever, and the Greek physician Hippocrates wrote about its medicinal properties in the 5th century BC. Native Americans across the American continent relied on it as a staple of their medical treatments.

Willow is used to treat headache and as an antipyretic due to the content of salicylic acid

In 1763 its medicinal properties were observed by the Reverend Edward Stone in England. He notified the Royal Society who published his findings. The active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the acid in its pure state. Salicin is acidic when in a saturated solution in water (pH = 2.4), and is called salicylic acid for that reason.

In 1897 Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the Spiraea plant), which caused less digestive upset than pure salicylic acid. The new drug, formally Acetylsalicylic acid, was named aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs).

Other uses

Uses as a plant

Agroforestry, Biofiltration, Constructed wetlands, Ecological wastewater treatment systems, Hedges, Land reclamation, Landscaping, Phytoremediation, Streambank stabilisation (bioengineering), Slope stabilisation, Soil erosion control, Shelterbelt & windbreak, Soil building, Soil reclamation, Tree bog compost toilet, Wildlife habitat

Uses as energy source

Charcoal, Energy forestry such as the Willow Biomass Project

Uses of wood

Basket weaving, Box, Brooms, Cricket bats, Cradle boards, Chairs & furniture, Dolls, Fish traps, Flutes, Poles, Sweat lodges, toys, turnery, tool handles, Veneer, Wands, Wattle fences, Wattle and daub, whistles

Uses of wood-derived products

Fibre plants, Paper, Rope and string, Tannin

• As part of the four species used on the Jewish holiday of Sukkot.
• Living Willow Sculpture

Herbal Plants : California Poppy

California Poppy to treat Toothache

The California poppy (Eschscholzia californica) is native to grassy and open areas from sea level to 2,000m (6,500 feet) altitude in the western United States throughout California, extending to Oregon, southern Washington, Nevada, Arizona, New Mexico, and in Mexico in Sonora and northwest Baja California.

It can grow 5–60 cm tall, with alternately branching glaucous blue-green foliage. The leaves are ternately divided into round, lobed segments. The flowers are solitary on long stems, silky-textured, with four petals, each petal 2-6 cm long and broad; their color ranges from yellow to orange, and flowering is from February to September. The fruit is a slender dehiscent capsule 3-9 cm long, which splits in two to release the numerous small black or dark brown seeds. It is perennial in mild parts of its native range, and annual in colder climates; growth is best in full sun and sandy, well-drained, poor soil.

It grows well in disturbed areas and often recolonizes after fires. In addition to being planted for horticulture, revegetation, and highway beautification, it often colonizes along roadsides and other disturbed areas. It is drought-tolerant, self-seeding, and easy to grow in gardens.

History & Uses

Eschscholzia californica was the first named member of the genus Eschscholzia, which was named by the German botanist Adelbert von Chamisso after another botanist, Johann Friedrich von Eschscholtz, his friend and colleague on Otto von Kotzebue’s scientific expedition to California and the greater Pacific in the early 19th century.

The California poppy is the California state flower. It was selected as the state flower by the California State Floral Society in December 1890, winning out over the Mariposa lily (genus Calochortus) and the Matilija poppy (Romneya coulteri) by a landslide, but the state legislature did not make the selection official until 1903. Its golden blooms were deemed a fitting symbol for the Golden State. April 6 of each year is designated "California Poppy Day."

Horticulturalists have produced numerous cultivars with various other colors and blossom and stem forms. These typically do not breed true on reseeding.

A common myth associated with the plant is that cutting or otherwise damaging the California poppy is illegal because it is a state flower. There is no such law. There is a state law that makes it a misdemeanor to cut or remove any flower, tree, shrub or other plant growing on state or county highways, with an exception for authorized government employees and contractors (Cal. Penal Code Section 384a).

California poppy leaves were used medicinally by Native Americans, and the pollen was used cosmetically. The seeds are used in cooking.

Extract from the California poppy acts as a mild sedative when smoked. The effect is far milder than that of opium, which contains a different class of alkaloids.

The Antelope Valley California Poppy Reserve is located in northern Los Angeles County, California. At the peak of the blooming season, orange petals seem to cover all 1,745 acres (7 km²) of the reserve.

info : wikipedia

Citrus medica = lime

CITRON or LIME

useful in heart disorders

The Citron is a fragrant fruit with the botanical name Citrus medica L. which apply to both, the Swingle and Tanaka systems. It is a prominent member in the genus Citrus belonging to the Rutaceae or Rue family, sub-family Aurantoideae. Its different names Citrus Media, Median Apple etc. were influenced by the Theophrastus who considered it being native to Media, Persia or Assyria. However, those names are now rarely in use.

Citron is useful in heart disorders, abdominal colic, Gulm, vomiting, nausea, indigestion, heamorrhoids

The citron is not the ordinary citrus fruit like the Lemon or Orange. While the most popular citrus species are peeled off in order to consume the inner pulpy and juicy segments – the citron contains extreme dry pulp which has little value compared to the orange. Moreover, its main content is the thick white rind which is extremely adherent to the segments, and cannot peel off at all.

Thus, the Citron was from ancient through medieval times mainly used only for the fragrance of its outer peel or for derived medicine against seasickness, pulmonary troubles, intestinal ailments and other disorders. Citron juice with wine was considered an effective antidote to poison. The essential oil of the peel was regarded as an antibiotic.

The most important part of the citron is the peel which is a fairly important article in international trade. The fruits are halved, depulped, immersed in seawater or ordinary salt water to ferment for about 40 days, the brine being changed every 2 weeks; rinsed, put in denser brine in wooden barrels for storage and for export. After partial de-salting and boiling to soften the peel, it is candied in a strong sugar solution. The candied peel is sun-dried or put up in jars for future use. Candying is done mainly in England, France and the United States. The candied peel is widely employed in the food industry, especially as an ingredient in fruit cake, plum pudding, buns, sweet rolls and candy.

Today there is an uprising market for the citron is the United States for the soluble fiber which is found in its thick rind, also called albedo. The citron is also used by Jews for a religious ritual during the Feast of Tabernacles, by whom it is called Etrog.

The citron has many similar names in diverse languages, e.g. cederat, cedro, etc. Most confusing is the French language, in which the false friend "citron" refers to a lemon in English (similarly, "limon" is the French word for lime).

The citron has been cultivated since ancient times, predating cultivation of other citrus species. Despite its minor importance today being hardly consumed as is, it seems that in different times it played a big role in life. We could see that from the way how it was described by numerous writings and poets across centuries. It is suggested that when the other citrus species arrived, they pushed the citron off the road, since most of its benefits could nearly by found in the lemon, which is much easier to cultivate.

The following is from the writings of Theophrastus

"In the east and south there are special plants... i.e. in Media and Persia there are many types of fruit, between them there is a fruit called Median or Persian Apple. The tree has a leaf similar to and almost identical with that of the andrachn (Arbutus andrachne L.), but has thorns like those of the apios (the wild pear, Pyrus amygdaliformis Vill.) or the oxyacanthos (the fire thorn, Cotoneaster pyracantha Spach.), except that they are white, smooth, sharp and strong.

"The fruit is not eaten, but is very fragrant, as is also the leaf of the tree; and the fruit is put among clothes, it keeps them from being moth-eaten. It is also useful when one has drunk deadly poison, for when it is administered in wine; it upsets the stomach and brings up the poison. It is also useful to improve the breath, for if one boils the inner part of the fruit in a dish or squeezes it into the mouth in some other medium, it makes the breath more pleasant.

"The seed is removed from the fruit and sown in the spring in carefully tilled beds, and it is watered every fourth or fifth day. As soon the plant is strong it is transplanted, also in the spring, to a soft, well watered site, where the soil is not very fine, for it prefers such places.

"And it bears its fruit at all seasons, for when some have gathered, the flower of the others is on the tree and is ripening others. Of the flowers I have said those which have a sort of distaff [meaning the pistil] projecting from the middle are fertile, while those which do not have this are sterile. It is also sown, like date palms, in pots punctured with holes.

"This tree, as has been remarked, grows in Media and Persia."

Later with about 400 years it was also described by Pliny the Elder, who was calling it nata Assyria malus.

"The Assyrian fruit, which some call Median, is an antidote for poisons. Its leaf is like that of the andrachn (Arbutus andrachne L.), but with thorns running between. The fruit is notable for the fact that it is not eaten and has a strong odor, as also do the leaves, which impregnates clothes stored with them and keeps away harmful insects.

"The tree itself bears fruit continuously; some dropping off, others ripening, and still others budding.

"People have tried to introduce the tree into their land in clay vessels because of its medicinal efficacy, providing breathing for the roots by making holes in the vessels; …but except among Media and in Persia, it has refused to grow.

"This is the fruit whose pips we have related Parthian nobles boiled in foods in order to eliminate bad breath. No other tree is so highly praised in Media."

info : wikipedia

Acorus calamus - Sweet Flag

Sweet Flag For Medicine

Calamus or Common Sweet Flag (Acorus calamus) is a plant from the Acoraceae family, Acorus genues. It is a tall perennial wetland monocot with scented leaves and rhizomes which have been used medicinally, for its odor, and as a psychotropic drug. It is known by a variety of names, including cinnamon sedge, flagroot, gladdon, myrtle flag, myrtle grass, myrtle sedge, sweet cane, sweet myrtle, sweet root, sweet rush, and sweet sedge. Probably indigenous to India, Acorus calamus is now found across Europe, in southern Russia, northern Asia Minor, southern Siberia, China, Japan, Burma, Sri Lanka, and northern USA.

The morphological distinction between the Acorus species is made by the number of prominent leaf veins. Acorus calamus has a single prominent midvein and then on both sides slightly raised secondary veins (with a diameter less than half the midvein) and many, fine tertiary veins. This makes it clearly distinct from Acorus americanus.

The leaves are between 0.7 and 1.7 cm wide, with average of 1 cm. The sympodial leaf of Acorus calamus is somewhat shorter than the vegetative leaves. The margin is curly-edged or undulate. The spadix, at the time of expansion, can reach a length between 4.9 and 8.9 cm (longer than A. americanus). The flowers are longer too, between 3 and 4 mm. Acorus calamus is infertile and shows an abortive ovary with a shriveled appearance.

Calamus has been an item of trade in many cultures for thousands of years. Calamus has been used medicinally for a wide variety of ailments.

In antiquity in the Orient and Egypt, the rhizome was thought to be a powerful aphrodisiac. In Europe Acorus calamus was often added to wine, and the root is also one of the possible ingredients of absinthe. Among the northern Native Americans, it is used both medicinally and as a stimulant; in addition, the root is thought to have been used as an entheogen among the northern Native Americans. In high doses, it is hallucinogenic.

Characteristic: Bitter tonic, ague, habitual constipation, atonic dyspepsia, flatulence, paralytic nervous affections, colic, epilepsy, dropsy, glandular diseases, rheumatoc swellings, useful for children's ailments teething etc.

The calamus has long been a symbol of male love. The name is associated with a Greek myth: Kalamos, a son of the river-god Maeander, who loved Karpos, the son of Zephyrus and Chloris. When Karpos drowned, Kalamos was transformed into a reed, whose rustling in the wind was interpreted as a sigh of lamentation.

The plant was a favorite of Henry David Thoreau (who called it sweet flag), and also of Walt Whitman, who added a section called The Calamus Poems, celebrating the love of men, to the third edition of Leaves of Grass (1860). In the poems the calamus is used as a symbol of love, lust, and affection. It has been suggested that the symbology derives from the visual resemblance of the spadix to the erect human penis.

The name Sweet Flag refers to its sweet scent (it has been used as a strewing herb) and the wavy edges of the leaves which are supposed to resemble a fluttering flag.

In Japan, the plant is a symbol of the samurai's bravery because of its sharp sword-like leaves. Even now many families with young boys enjoy "Sweet Flag Bath (shōbu yu)" in the Boy's Festival (Tango no Sekku) on May 5.

info : wikipedia

Aloe Vera

Aloe Vera For Medical Treatment

Superregnum: Eukaryota
Regnum: Plantae
Divisio: Magnoliophyta
Classis: Liliopsida
Subclassis: Liliidae
Ordo: Asparagales
Familia: Asphodelaceae
Genus: Aloe Species: Aloe vera

Useful in ophthalmic disorders, mild laxative, tonic, increases semen quality, cure vata dosha, poisonous effects, hepatospleenomegaly, spleen and liver disorders, cystic formation, hydrocele, kaphha fever, glands, anomalies of blood, anomalies of skin.

ASTHMA

Asthma Disease

Asthma is defined as a respiratory disease caused by narrowing of the air passages. It is synonymous with difficulty in breathing, tightness of chest, nasal irritation, coughing and wheezing. The first person to use it in reference to a medical condition was Hippocrates in 450 BC, and he believed that tailors, anglers and metalworkers were more likely to be affected by the disease. Although much research has been done since, the inflammatory component of asthma was recognized only in the 1960s.

Today, asthma affects as much as 15% of the Canadian population (and this is true of other developed countries too) and has increased four fold in the last 20 years. Various reasons can be identified for this increase - Of course better diagnosis and facilities along with a greater awareness regarding the disease have played a major role. But, one cannot deny the part of increased environmental pollution. Researchers have been working on the relation between the environment and human health since long and the air we breathe is the primary cause for lung diseases like asthma, rhinitis, COPDs, etc. that affect us today.

Approximately 10 to 15% of the adults affected by the disease report an aggravation of their symptoms while at work and an improvement when away, which implies that they may be suffering from Occupational Asthma. Thus, when an individual’s Asthma is caused, not aggravated, by workplace materials, it is defined as Occupational Asthma. In the USA, OA is considered the most common occupational lung disease. At present, over 400 workplace substances have been identified as having asthmagenic or allergenic properties. Their existence and magnitude vary from region to region and the type of industry and can be as varied as wood dust (cedar, ebony, etc.), persulfates (Hairsprays), zinc or even seafood like prawns. For example, in France the industries most affected in order of importance are Bakeries and cake-shops, automobile industry and hairdressers, whereas in Canada the principal cause is wood dust, followed by isocyanates.

SIGNS & SYMPTOMS

Less than five years of exposure to an occupational agent can be enough for the appearance of the first OA symptoms. This depends on whether the reason for the OA to occur was exposure to the causative agent over a period of time (with a latency period) or a single exposure to an irritant but at a very high concentration (without latency period). Both eventually result in OA. Coughing, wheezing, nasal irritation, difficulty in breathing, tightness of chest are the most common symptoms and can be recognized more easily by asking oneself the following questions:

1. Are any of the above symptoms recurrent/chronic?
2. Are they present at work?
3. Do they worsen towards the end of the work day and/or end of the week?
4. Does the employee/worker feel an improvement in his condition when away from work, on vacation or on weekends?

If these symptoms persist, the person is most likely suffering from OA. However, one must be aware that this could also be because the person is already suffering from asthma and his condition was simply aggravated by workplace irritants (Work-aggravated asthma). In this case, although he will suffer similar consequences as someone who is suffering from OA (loss of work, medical expenses, etc.), his disease cannot be considered as having an occupational origin.

PREVENTION & TREATMENT

According to the Canadian Centre for Occupational Health and Safety (CCOHS) better education of workers, management, unions and medical professionals is the key to the prevention of OA. This will enable them to identify the risk factors and put in place preventive measures like masks or exposure limits, etc.

Recovery is directly dependent on the duration and level of exposure to the causative agent. Depending on the severity of the case, the condition of the patient can improve dramatically during the first year after removal from exposure.

Three basic types of procedures are used for treating the affected workers:

1) Reducing exposure

This method is most effective for those affected by irritant-induced OA. Thus, by reducing their exposure duration and level to the causative agent, the probability of suffering another reaction is lowered. But exposure can be reduced in other ways like making use of face masks or providing better ventilation. Now, more and more di-isocyanate free spray paints are available. Similarly, most hospitals and healthcare companies have exchanged latex gloves for other materials. Thus, reducing exposure to known asthmagens can also be used as a preventive measure.

2) Removal from exposure

Persons affected by OA that occurred after a latency period, whether a few months or years, must be immediately removed from exposure to the causative agent. This is their only chance of recovery. However, this entails severe socio-economic consequences for the worker as well as the employer due to loss of job, unemployment, compensation issues, quasi-permanent medical expenditures, hiring and re-training of new personnel, etc. Also, according to recent research the probability that those who suffer from OA remain unemployed longer than those who suffer from non-occupational asthma is higher. One solution to this problem is relocating the employee in the same company away from the causative agents.

3) Medical and pharmacological treatment

Anyone diagnosed with Asthma will have to undergo medical treatment. This is complementary to either removing or reducing the patient’s exposure to the causal agents. Two types of medication can be used:

• Relievers or bronchodilators

• Short-acting beta-agonists like salbutamol or terbutaline or long-acting beta-agonists like salmeterol and formoterol or anticholinergic, etc. dilate airways which relieve the symptoms thus reducing the severity of the reaction. Some patients also use it just before work to avoid a drop in the FEV¹.

• Preventers
• Anti-inflammatory agents like corticosteroids, LKTRA or mast cell stabilizers can be used depending on the severity of the case.

Gigantism

YOUR BODY BECOME LIKE A GIANT

Gigantism or giantism, (from Greek gigas, gigantas "giant") is a condition characterized by excessive height growth and bigness significantly above average height. As a medical term, gigantism is rarely used except to refer to the rare condition of pituitary gigantism due to prepubertal growth hormone excess. There is no precise definition of the degree of height that qualifies a person to be termed a "giant." The term has been typically applied to those whose height is not just in the upper 1% of the population but several standard deviations above mean for persons of the same sex, age, and ethnic ancestry. Typical adult heights of Americans of European descent to whom the term might be applied are 2.25 - 2.40 metres (7'6" - 8 feet). The term is not applied to those whose heights appear to be the healthy result of normal genetics and nutrition.

Pituitary growth hormone excess is the single condition that accounts for nearly all cases of pathologic extreme height. The excess growth hormone usually results from oversecretion by a group of somatotrope cells of the anterior pituitary gland (termed a "somatotrope adenoma"). These cells do not respond to normal controls of growth or function. They grow very slowly, so that for many years the only effects of such an adenoma are the secretion of excessive growth hormone. Over decades, such an adenoma may reach a large enough size (20 mm or more in diameter) to cause headaches, impair vision, or damage other pituitary functions. Many years of growth hormone excess can cause other problems as well.

The primary effect of growth hormone excess in childhood is excessive growth, but the extreme height is accompanied by a characteristic physique recognizable to an endocrinologist. The typical physique involves heavy, thick bones, with large hands and feet and a heavy jaw. Once puberty is complete and adult height is achieved, continued thickening of the skin and growth of the jaw results in a combination of features referred to as acromegaly.

If a physician suspects pituitary gigantism or acromegaly, the simplest diagnostic screening test is measurement of insulin-like growth factor 1 in the blood. This is usually quite elevated but levels must be interpreted in relation to age and pubertal status. Additional confirmatory testing may include magnetic resonance imaging (MRI) of the pituitary to look for a visible adenoma, and suppressibility of growth hormone levels by glucose. Treatment depends on the size of the adenoma and may involve removal by a neurosurgeon, drugs such as octreotide or bromocriptine, or radiation. Treatment is discussed in more detail in the acromegaly article.

Childhood pituitary gigantism is a rare condition, and those affected are often unusual enough to attain a degree of celebrity status (for example, André the Giant and The Great Khali). Acromegaly is the term used for the condition of growth hormone excess when it occurs in adults. Acromegaly is a far more common disease in adults than pituitary gigantism is in children.

Children who are excessively tall are often referred to as Giantigionists. The majority of children who seem excessively tall or large to their parents usually have a combination of simple familial tallness and childhood obesity.

Early onset of obesity results in above-average growth in mid-childhood, such that over half of overweight children have heights in the 70 - 99 percentile range at around 10 years of age. The adult heights achieved by these children are what would be expected from their families because the excess mid-childhood growth is offset by attenuation of the pubertal growth spurt.

Precocious puberty and a variety of conditions associated with excessive amounts of testosterone or estrogen in childhood will result in tallness by mid-childhood. However, the acceleration of bone maturation by the early rise of estradiol results in early completion of growth, and adult heights for these children may actually be below average for genetic potential.

Extra sex chromosomes (beyond the normal two) with therefore extra copies of the SHOX gene (beyond the normal two) usually results in enhancement of height growth. The most common of these karyotypes are 47,XXY (Klinefelter syndrome), 47,XYY, and 47,XXX. The added height increment is usually modest.

Hypogonadism is the condition of deficiency of sex hormones due to reduced function of the testes or ovaries at adolescence. When secretion of testosterone or estradiol remains below average throughout the teenage years, a taller adult height will be gradually achieved by extra growth of the arms and legs. This long-limbed tallness is termed "eunuchoid" tallness, but rarely adds more than 25 mm - 75 mm (1-3 in) to adult height. The extra growth is prevented if the child is given appropriate replacement of testosterone or estrogen from early adolescence.

A very rare but more extreme version of "eunuochoid" tallness occurs when a mutation of the estrogen receptor reduces the response of the bones to estradiol. Estradiol is a byproduct of testosterone in both males and females, and is the most potent accelerator of bone maturation and closure known. If a person fails to respond to estrogen, growth can continue until late-20s or longer, and the affected person can reach 8 feet or more in height. Estrogen resistance is the only other endocrine condition that can rival growth hormone excess in producing gigantism. In contrast, the tallness associated with the more common androgen insensitivity syndrome averages only a few inches, as estradiol is not produced directly but rather through conversion from androgens by aromatase.

Marfan syndrome is an uncommon genetic disease due to an inherited defect of connective tissue. In addition to moderate tallness, persons with this condition usually have a slender body build with unusually long fingers (arachnodactyly). Many can also develop a dislocaton of the lens of the eye or, more seriously, a progressive deterioration of the walls of the aorta which can result in sudden death in adulthood. It is usually inherited as an autosomal dominant trait.

Sotos syndrome resembles acromegaly in its mild distortion of facial growth. In addition to tallness, the chief characteristics are large head size, slow development, and autosomal-dominant inheritance.

There are about 50 even rarer genetic syndromes in which childhood growth is above average. These conditions are often associated with developmental delay or other more serious problems, and adult height may or may not be mildly increased.

Genetic Disease

GENETIC DISORDER = DISEASE

A genetic disorder is a condition caused by abnormalities in genes or chromosomes. While some diseases, such as cancer, are due to genetic abnormalities acquired in a few cells during life, the term "genetic disease" most commonly refers to diseases present in all cells of the body and present since conception. Some genetic disorders are caused by chromosomal abnormalities due to errors in meiosis, the process which produces reproductive cells such as sperm and eggs. Examples include Down syndrome (extra chromosome 21), Turner Syndrome (45X0) and Klinefelter's syndrome (a male with 2 X chromosomes). Other genetic changes may occur during the production of germ cells by the parent. One example is the triplet expansion repeat mutations which can cause fragile X syndrome or Huntington's disease. Defective genes may also be inherited intact from the parents. In this case, the genetic disorder is known as a hereditary disease. This can often happen unexpectedly when two healthy carriers of a defective recessive gene reproduce, but can also happen when the defective gene is dominant.

Currently around 4,000 genetic disorders are known, with more being discovered. Most disorders are quite rare and affect one person in every several thousands or millions. Cystic fibrosis is one of the most common genetic disorders; around 5% of the population of the United States carry at least one copy of the defective gene. Some types of recessive gene disorder confer an advantage in the heterozygous state in certain environments.

Genetic diseases are typically diagnosed and treated by geneticists. Genetic counselors assist the physicians and directly counsel patients. The study of genetic diseases is a scientific discipline whose theoretical underpinning is based on population genetics.

Where genetic disorders are the result of a single mutated gene they can be passed on to subsequent generations in the ways outlined in the table below. Genomic imprinting and uniparental disomy, however, may affect inheritance patterns. The divisions between recessive and dominant are not "hard and fast" although the divisions between autosomal and X-linked are (related to the position of the gene). For example, achondroplasia is typically considered a dominant disorder, but children with two genes for achondroplasia have a severe skeletal disorder that achondroplasics could be viewed as carriers of. Sickle-cell anemia is also considered a recessive condition, but carriers that have it by half along with the normal gene have increased immunity to malaria in early childhood, which could be described as a related dominant condition.

Genetic disorders may also be complex, multifactorial or polygenic, this means that they are likely associated with the effects of multiple genes in combination with lifestyle and environmental factors. Multifactoral disorders include heart disease and diabetes. Although complex disorders often cluster in families, they do not have a clear-cut pattern of inheritance. This makes it difficult to determine a person’s risk of inheriting or passing on these disorders. Complex disorders are also difficult to study and treat because the specific factors that cause most of these disorders have not yet been identified.

On a pedigree, polygenic diseases do tend to “run in families”, but the inheritance does not fit simple patterns as with Mendelian diseases. But this does not mean that the genes cannot eventually be located and studied. There is also a strong environmental component to many of them (e.g., blood pressure).

• autism
• heart disease
• hypertension
• diabetes
• obesity
• cancers
• cleft palate
• Mental retardation

Beware Of Breast Cancer

Breast cancer is a cancer of the glandular breast tissue.
Worldwide, breast cancer is the fifth most common cause of cancer death (after lung cancer, stomach cancer, liver cancer, and colon cancer). In 2005, breast cancer caused 502,000 deaths (7% of cancer deaths; almost 1% of all deaths) worldwide. Among women worldwide, breast cancer is the most common cause of cancer death.

In the United States, breast cancer is the third most common cause of cancer death (after lung cancer and colon cancer). In 2007, breast cancer is expected to cause 40,910 deaths (7% of cancer deaths; almost 2% of all deaths) in the U.S. Among women in the U.S., breast cancer is the most common cancer and the second-most common cause of cancer death (after lung cancer). Women in the U.S. have a 1 in 8 lifetime chance of developing invasive breast cancer and a 1 in 33 chance of breast cancer causing their death. In the U.S., both incidence and death rates for breast cancer have been declining in the last few years. Nevertheless, a U.S. study conducted in 2005 by the Society for Women's Health Research indicated that breast cancer remains the most feared disease, even though heart disease is a much more common cause of death among women.
The number of cases worldwide has significantly increased since the 1970s, a phenomenon partly blamed on modern lifestyles in the Western world. Because the breast is composed of identical tissues in males and females, breast cancer also occurs in males, though it is less common.

Prevention

A. Phytoestrogens and soy
Phytoestrogens such as found in soybeans have been extensively studied in animal and human in-vitro and epidemiological studies. The literature support the following conclusions:

1. Plant estrogen intake, such as from soy products, in early adolescence may protect against breast cancer later in life.
2. Plant estrogen intake later in life is not likely to influence breast cancer incidence either positively or negatively.

B. Folic Acid C. Avoiding exposure to secondhand tobacco smoke

Treatment

The mainstay of breast cancer treatment is surgery when the tumor is localized, with possible adjuvant hormonal therapy (with tamoxifen or an aromatase inhibitor), chemotherapy, and/or radiotherapy. At present, the treatment recommendations after surgery (adjuvant therapy) follow a pattern. This pattern is subject to change, as every two years, a worldwide conference takes place in St. Gallen, Switzerland, to discuss the actual results of worldwide multi-center studies. Depending on clinical criteria (age, type of cancer, size, metastasis) patients are roughly divided to high risk and low risk cases, with each risk category following different rules for therapy. Treatment possibilities include radiation therapy, chemotherapy, hormone therapy, and immune therapy.
In planning treatment, doctors can also use PCR tests like Oncotype DX or microarray tests like MammaPrint that predict breast cancer recurrence risk based on gene expression. In February 2007, the MammaPrint test became the first breast cancer predictor to win formal approval from the Food and Drug Administration. This is a new gene test to help predict whether women with early-stage breast cancer will relapse in 5 or 10 years, this could help influence how aggressively the initial tumor is treated.

Stroke

Stroke = Brain Attack

Stroke (or cerebrovascular accident (CVA)) is the clinical designation for a rapidly developing loss of brain function due to an interruption in the blood supply to all or part of the brain. This phenomenon can be caused by thrombosis, embolism, or hemorrhage. In medicine, the process of being struck down by a stroke, fit, or faint is sometimes called an ictus [cerebri], from the Latin icere ("to strike"), especially prior to a definitive diagnosis.

Stroke is a medical emergency and can cause permanent neurological damage and death if not promptly diagnosed and treated. It is the third leading cause of death and the leading cause of adult disability in the United States and Europe. It is predicted that stroke will soon become the leading cause of death worldwide.

The symptoms of stroke can be quite heterogeneous, and patients with the same cause of stroke can have widely differing handicaps. Conversely, patients with the same clinical handicap can in fact have different underlying causes.

The cause of stroke causeing neurons to die or be seriously damaged, further impairing brain function.

Risk factors for stroke include advanced age, hypertension (high blood pressure), previous stroke or TIA (transient ischaemic attack), diabetes mellitus, high cholesterol, cigarette smoking, atrial fibrillation, migraine with aura, and thrombophilia. In clinical practice, blood pressure is the most important modifiable risk factor of stroke; however many other risk factors, such as cigarette smoking cessation and treatment of atrial fibrillation with anticoagulant drugs, are important.

Signs & Symptoms

The symptoms of stroke depend on the type of stroke and the area of the brain affected. Ischemic strokes usually only affect regional areas of the brain perfused by the blocked artery. Hemorrhagic strokes can affect local areas, but often can also cause more global symptoms due to bleeding and increased intracranial pressure.

If the area of the brain affected contains one of the three prominent Central nervous system pathways—the spinothalamic tract, corticospinal tract, and dorsal column (medial lemniscus), symptoms may include:

• hemiplegia and muscle weakness of the face
• numbness
• reduction in sensory or vibratory sensation

In most cases, the symptoms affect only one side of the body. The defect in the brain is usually on the opposite side of the body (depending on which part of the brain is affected). However, the presence of any one of these symptoms does not necessarily suggest a stroke, since these pathways also travel in the spinal cord and any lesion there can also produce these symptoms.

In addition to the above CNS pathways, the brainstem also consists of the 12 cranial nerves. A stroke affecting the brainstem therefore can produce symptoms relating to deficits in these cranial nerves:

• altered smell, taste, hearing, or vision (total or partial)
• drooping of eyelid (ptosis) and weakness of ocular muscles
• decreased reflexes: gag, swallow, pupil reactivity to light
• decreased sensation and muscle weakness of the face
• balance problems and nystagmus
• altered breathing and heart rate
• weakness in sternocleidomastoid muscle with inability to turn head to one side
• weakness in tongue (inability to protrude and/or move from side to side)

If the cerebral cortex is involved, the CNS pathways can again be affected, but also can produce the following symptoms:

• aphasia (inability to speak or understand language from involvement of Broca's or Wernicke's area)
• apraxia (altered voluntary movements)
• visual field defect
• memory deficits (involvement of temporal lobe)
• hemineglect (involvement of parietal lobe)
• disorganized thinking, confusion, hypersexual gestures (with involvement of frontal lobe)

If the cerebellum is involved, the patient may have the following:

• trouble walking
• altered movement coordination
• vertigo and or disequilibrium

Loss of consciousness, headache, and vomiting usually occurs more often in hemorrhagic stroke than in thrombosis because of the increased intracranial pressure from the leaking blood compressing on the brain.

If symptoms are maximal at onset, the cause is more likely to be a subarachnoid hemorrhage or an embolic stroke.

Risk factors and prevention

Prevention of stroke can work at various levels including:

1. primary prevention - the reduction of risk factors across the board, by public health measures such as reducing smoking and the other behaviours that increase risk;
2. secondary prevention - actions taken to reduce the risk in those who already have disease or risk factors that may have been identified through screening; and
3. tertiary prevention - actions taken to reduce the risk of complications (including further strokes) in people who have already had a stroke.

The most important modifiable risk factors for stroke are hypertension, heart disease, diabetes, and cigarette smoking. Other risks include heavy alcohol consumption (see Alcohol consumption and health), high blood cholesterol levels, illicit drug use, and genetic or congenital conditions. Family members may have a genetic tendency for stroke or share a lifestyle that contributes to stroke. Higher levels of Von Willebrand factor are more common amongst people who have had ischemic stroke for the first time. The results of this study found that the only significant genetic factor was the person's blood type. Having had a stroke in the past greatly increases one's risk of future strokes.

One of the most significant stroke risk factors is advanced age. 95% of strokes occur in people age 45 and older, and two-thirds of strokes occur in those over the age of 65. A person's risk of dying if he or she does have a stroke also increases with age. However, stroke can occur at any age, including in fetuses.

Sickle cell anemia, which can cause blood cells to clump up and block blood vessels, also increases stroke risk. Stroke is the second leading killer of people under 20 who suffer from sickle-cell anemia.

Men are 1.25 times more likely to suffer strokes than women, yet 60% of deaths from stroke occur in women. Since women live longer, they are older on average when they have their strokes and thus more often killed (NIMH 2002). Some risk factors for stroke apply only to women. Primary among these are pregnancy, childbirth, menopause and the treatment thereof (HRT). Stroke seems to run in some families.

Prevention is an important public health concern. Identification of patients with treatable risk factors for stroke is paramount. Treatment of risk factors in patients who have already had strokes (secondary prevention) is also very important as they are at high risk of subsequent events compared with those who have never had a stroke. Medication or drug therapy is the most common method of stroke prevention. Aspirin (usually at a low dose of 75 mg) is recommended for the primary and secondary prevention of stroke. Also see Antiplatelet drug treatment. Treating hypertension, diabetes mellitus, smoking cessation, control of hypercholesterolemia, physical exercise, and avoidance of illicit drugs and excessive alcohol consumption are all recommended ways of reducing the risk of stroke.

In patients who have strokes due to abnormalities of the heart, such as atrial fibrillation, anticoagulation with medications such as warfarin is often necessary for stroke prevention.

Procedures such as carotid endarterectomy or carotid angioplasty can be used to remove significant atherosclerotic narrowing (stenosis) of the carotid artery, which supplies blood to the brain. These procedures have been shown to prevent stroke in certain patients, especially where carotid stenosis leads to ischemic events such as transient ischemic attack. (The value and role of carotid artery ultrasound scanning in screening has yet to be established.)

info : wikipedia